Skip to main content
Premium Trial:

Request an Annual Quote

Two New RNAi-Related Patent Application Published By US Patent Office

Premium

Title: Treatment of Melanoma by Reduction in Clusterin Levels. Number: 20040082534. Filed: Aug. 21, 2003. Lead Inventor: Martin Gleave, Vancouver General Hospital.

The patent application, its abstract states, covers the treatment of melanoma through “reduction in the effective amount of clusterin in melanoma cells … in a mammalian subject, preferably a human.”

The abstract states that “the therapeutics agent may be … a small inhibitory RNA [compound] targeted to clusterin. Bcl-xL in a subject or cell line can also be regulated by administering … an agent effective to modulate the amount of clusterin expression.”

The abstract adds that “such inhibition is significant because bcl-xL is known to act as an inhibitor of apoptosis.”


Title: Cctra Gene as a Tool to Produce Male-Only Progeny in the Mediterranean Fruitfly Ceratitis capitata. Number: 20040082032. Filed: Sept. 8, 2003 (PCT Filed: March 8, 2002). Lead Inventor: Pasquale Delli Bovi, Università di Napoli.

According to the patent application’s abstract, the invention”refers to the identification of the Cctra gene and to corresponding dsRNA molecules comprising Cctra gene sequences as a tool to produce only-male progeny in the Mediterranean fruitfly Ceratitis capitata.

 

The Scan

Vaccine Update Recommended

A US Food and Drug Administration panel recommends booster vaccines be updated to target Omicron, CNBC reports.

US to Make More Vaccines for Monkeypox Available

The US is to make nearly 300,000 vaccine doses available in the coming weeks to stem the spread of human monkeypox virus, according to NPR.

Sentence Appealed

The Associated Press reports that Swedish prosecutors are appealing the sentence given to a surgeon once lauded for transplanting synthetic tracheas but then convicted of causing bodily harm.

Genome Biology Papers on COVID-19 Effector Genes, Virtual ChIP-seq, scDART

In Genome Biology this week: proposed COVID-19 effector genes, method to predict transcription factor binding patterns, and more.