Skip to main content
Premium Trial:

Request an Annual Quote

Tuschl-I Patent Upheld in Europe

Premium

Alnylam Pharmaceuticals and the University of Massachusetts Medical School last week announced that the European Patent Office has upheld the claims in a patent from the key Tuschl-I family of intellectual property, which covers the use of siRNAs to induce gene silencing.

The patent, EP 1309726, had been opposed by Sanofi-Aventis, Silence Therapeutics, and BASF, according to Alnylam. It is owned by the Max Planck Society, the Massachusetts Institute of Technology, the Whitehead Institute for Biomedical Research, and UMMS.

"We are very pleased with the outcome of these opposition proceedings, which resulted in the claims from the Tuschl I '726 patent being fully upheld,” Alnylam CBO Laurence Reid said in a statement. “This decision by the EPO affirms our belief in the validity of these claims and the novelty of the Tuschl-I invention, and supports the relevance of Tuschl-I for the development and commercialization of RNAi therapeutics."

The Tuschl-I IP, along with a related patent family known as Tuschl-II, had been the subject of a legal dispute between its assignees.

That matter was settled about a year ago (GSN 3/17/2011).

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.