TransDerm, a small biotech focused on developing a treatment for pachyonychia congenita (PC), has just kicked off a phase I trial of a new drug candidate designed to treat the rare skin condition.

However, while the company had been focused on using RNAi as foundation for its products, the new trial is testing a product based on sirolimus, a macrolide immunosuppressant commonly used to prevent organ rejection in transplant patients.

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