By Doug Macron

TransDerm, which is developing an siRNA-based treatment for a rare skin disorder, has begun evaluating a variety of different drug-delivery technologies that it hopes will improve the performance of the drug that was observed in a recent phase Ib study.

This week, the company announced that it has formed a research alliance with RXi Pharmaceuticals to evaluate RXi's proprietary RNAi compounds, including its so-called self-delivering rxRNAs, in dermatology models.

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Technology Review reports that researchers in the US have used CRISPR to modify a number of human embryos.

Plant researchers plan to sequence some 10,000 samples that represent the major plant clades, ScienceInsider reports.

By introducing genes from butterfly peas and Canterbury bells, researchers in Japan have developed a blue chrysanthemum, according to NPR.

In Nature this week: a Danish reference genome, and more.