In an effort to improve the screening and selection of lipid nanoparticle delivery vehicles for siRNA therapeutics, researchers from Merck have developed an in vitro assay designed to test how the particles will behave in vivo.

After systemic administration, lipid nanoparticles are exposed to a variety of biological elements such as serum proteins and blood proteins that can affect their ability to effectively carry RNAi payloads to target tissues.

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