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NEW YORK (GenomeWeb) – As part of their effort to develop an RNAi-based therapy for hepatitis B infection, researchers from the University of the Witwatersrand in South Africa have developed self-inactivated lentiviral vectors that generate liver-specific microRNA-based RNAi activators that target different portions of the virus's genome.

In addition to their potential for the treatment of HBV, the vectors may also be applicable to other hepatic viral infections and the ex vivo modification of hepatocytes or induced hepatocyte progenitors.

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