Tools & Techniques: Abasic Substitutions in siRNAs; Lipid Nanoparticle Evaluation; and More | GenomeWeb

As part of an effort to develop RNAi-based therapies for conditions caused by CAG repeat expansions, researchers from Alnylam Pharmaceuticals and the University of Texas Southwestern Medical Center have reported on the use of abasic substitutions to create siRNAs with tailored activity.

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