Tools & Techniques: 3D Microtissue Co-culture System for RNAi Screens; Exosomes for Nucleic Acid Delivery; and More | GenomeWeb

Although high-throughput RNAi screens are widely used to identify novel drug targets, few hits turn out to be robust enough in follow-on preclinical validation, in part because of the differences between the behavior and response of cells grown in 2D monolayers compared with those grown in vivo following gene perturbation.

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