Tekmira Pharmaceuticals said last week that it has stopped a phase I study of its siRNA-based hypercholesterolemia drug ApoB SNALP.

While the drug was well tolerated and showed some signs of clinical activity, Tekmira said that it has put the phase I program on hold in order to select a new siRNA and drug-delivery formulation for development. The new agent is expected to be "several-fold more potent than the current formulation," the company said.

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