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Tekmira Enrolls Patients in New Ebola Drug Trial

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Tekmira Pharmaceuticals this week announced that it has dosed the first patients in a phase I trial of its next-generation Ebola virus drug TKM-Ebola.

The company is developing the drug under a contract from the US Department of Defense that could be worth up to $140 million and fund the drug's development through to commercialization. Tekmira had previously tested an earlier version in phase I, but cut that trial short in order to incorporate improvements to its lipid nanoparticle delivery vehicles.

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.