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Tekmira, Collaborators Demonstrate HCV Knockdown In Vivo with RNAi


Tekmira Pharmaceuticals this week announced that, along with collaborators at SomaGenics and Roche, it has shown in vivo efficacy of an RNAi molecule against hepatitis C virus.

“In this work, short hairpin RNAs that target a conserved region of the HCV genome were delivered systemically using Tekmira's lipid nanoparticle technology, resulting in a significant and durable reduction in viral load in HCV-infected animals," Tekmira President and CEO Mark Murray said in a statement.

Specifically, shRNAs were taken up by liver cells in a chimeric mouse model, Tekmira said. Additionally, a single intravenous dose of the agent was sufficient to trigger “significant HCV reduction.”

The biggest effect was achieved with a cocktail of two shRNAs targeting two different sites on the HCV genome, with additional “potent and durable” inhibition after a second dose, the company added.

The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge is weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.