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Tekmira, Collaborators Demonstrate HCV Knockdown In Vivo with RNAi


Tekmira Pharmaceuticals this week announced that, along with collaborators at SomaGenics and Roche, it has shown in vivo efficacy of an RNAi molecule against hepatitis C virus.

“In this work, short hairpin RNAs that target a conserved region of the HCV genome were delivered systemically using Tekmira's lipid nanoparticle technology, resulting in a significant and durable reduction in viral load in HCV-infected animals," Tekmira President and CEO Mark Murray said in a statement.

Specifically, shRNAs were taken up by liver cells in a chimeric mouse model, Tekmira said. Additionally, a single intravenous dose of the agent was sufficient to trigger “significant HCV reduction.”

The biggest effect was achieved with a cocktail of two shRNAs targeting two different sites on the HCV genome, with additional “potent and durable” inhibition after a second dose, the company added.

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