Tekmira Begins Dosing Patients in Phase I Cancer Drug Study | GenomeWeb

Tekmira Pharmaceuticals said late last month that it has begun dosing patients in a phase I study of its cancer drug TKM-PLK1.

The drug targets polo-like kinase 1, or PLK1, a cell cycle protein involved in tumor cell proliferation and a validated oncology target, the company said.

The trial is an open label, multi-dose, dose-escalation study designed to evaluate the safety, tolerability, and pharmacokinetics of TKM-PLK1, and to determine the drug's maximum tolerated dose. It will trial will enroll up to 52 patients with advanced solid tumors.

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