Skip to main content
Premium Trial:

Request an Annual Quote

Tekmira Beginning Phase I/II Study of Cancer Drug in Liver Cancer Patients

Premium

NEW YORK (GenomeWeb) – Tekmira Pharmaceuticals this week announced that it is beginning a Phase I/II trial of its cancer drug TKM-PLK1 in patients with hepatocellular carcinoma (HCC).

TKM-PLK1 uses the company's proprietary lipid nanoparticles to deliver siRNAs against polo-like kinase 1, a serine/threonine kinase that is key to cell progression and is over-expressed in a number of cancer types.

The agent is already in a Phase I/II trial in patients with gastrointestinal neuroendocrine tumors or adrenocortical carcinoma. Interim data from that study is expected later this year.

The planned HCC trial is designed to test escalating doses of TKM-PLK1 in patients with advanced forms of the disease. It will study the drug's safety, tolerability, and clinical benefit.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.