Skip to main content
Premium Trial:

Request an Annual Quote

Tekmira Animals Data Shows Drug Can Protect Against Marburg 72 Hours after Infection

Premium

Tekmira Pharmaceuticals this week announced the release of new preclinical data showing that the company's RNAi-based Marburg virus drug could prevent death in non-human primates infected with a lethal dose of the pathogen.

The animals were infected with the virus, then given 0.5 mg/kg doses of the drug — TKM-Marburg — once a day for seven days 72 hours later. All of the treated primates survived.

Previously, Tekmira and collaborators at the University of Texas Medical Branch showed that TKM-Marburg could offer complete protection from lethal Marburg infection when given 24 hours and 48 hours after exposure.

In a presentation at the 6th International Symposium of Filoviruses this week, Tekmira Chief Technology Officer Ian MacLachlan said that forthcoming studies will test TKM-Marburg's efficacy in non-human primates 96 hours after Marburg infection.

Tekmira currently has a treatment for another filovirus, Ebola, in Phase I development. As reported by Gene Silencing News, the company recently received a National Institutes of Health grant to develop a single RNAi agent against both Ebola and Marburg viruses.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.