Skip to main content
Premium Trial:

Request an Annual Quote

Sylentis Cleared to Begin Phase I/II Trial of Ocular Hypertension Drug


Sylentis said this week that it has received clearance from Spanish regulators to begin a second phase I/II trial of its siRNA-based ocular hypertension drug SYL040012.

The drug targets adrenergic receptor beta-2 and is delivered topically to the eye. Earlier this summer, the company completed a phase Ia trial, finding the agent to be safe and well-tolerated in healthy volunteers (GSN 7/8/2010).

The new trial will enroll patients with elevated intraocular pressure. Sylentis aims to develop SYL040012 as a glaucoma treatment.

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.