On Success of One-Patient Study, TransDerm Aims to Advance siRNA Drug for Rare Skin Disorder | GenomeWeb

Data from a one-patient study of an investigational siRNA-based treatment for the rare skin disorder pachyonychia congenita indicates the drug is safe and potentially effective, an official from the company developing the therapy told RNAi News last week.

However, because the route of administration, intradermal injections, proved more painful than anticipated, a planned follow-up trial will likely use an investigational cream-based delivery vehicle, TransDerm Founder and CEO Roger Kaspar said.

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The White House has created a list of cuts, including to the NIH, that could be in a budget bill for this year.

The US National Institutes of Health is to allow applicants to cite preprints just as they would any other research paper, ScienceInsider reports.

Two manuscript pages handwritten by Charles Darwin are going on the auction block, according to the Los Angeles Times.

In PNAS this week: tool to track transcriptome-wide binding, evidence of balancing selection on behavior-linked genes, and more.