NEW YORK (GenomeWeb News) – In a study appearing online today in Science, a Massachusetts-based research team describes a genetic screening strategy it is using to tease apart a set of complex interactions between bacterial pathogens and their host cells.

The approach — dubbed "insertional mutagenesis and depletion," or iMAD — couples mutagenesis of bacterial DNA with RNA interference, which is then used to knock down host cell genes.

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