Stanford Team Identifies Argonaute Proteins as Key Players in RNAi Efficacy, Toxicity | GenomeWeb

By Doug Macron

A team of researchers led by Stanford University's Mark Kay earlier this month published data identifying the members of the human Argonaute family as the key players in the liver toxicity observed with high doses of shRNAs.

Notably, the findings also indicate that the toxic effects may not be solely the result of interference with the microRNA pathway, but also with other small regulatory RNAs that have yet to be identified.

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