Stanford Team Finds Robust shRNA Expression Can Be Toxic or Fatal; Sequence Selection, Dosing Key | GenomeWeb

A team of researchers from Stanford University has shown that sustained, high-level shRNA expression in murine livers can result in severe toxicity and death -- possibly as a result of the shRNAs interfering with endogenous microRNA processing machinery.

Although the findings, which appear in this week's Nature, have raised questions over the use of shRNA as a therapeutic modality, Mark Kay, a professor at Stanford's School of Medicine and co-author of the paper, called them "encouraging."

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