Title: Covalent Modification of RNA for In Vitro and In Vivo Delivery. Number: 20040167090. Filed: Feb. 19, 2004. Lead Inventor: Sean Monahan, Mirus.
According to the patent application’s abstract, the invention comprises “post-synthetic modification of RNA for the delivery of the RNA to a mammalian cell. The modifications enhance [resistance] of the RNA to nuclease digestion, and [enhance] delivery of the RNA to the cell whether the RNA is delivered alone or in combination with a transfection agent,” it states.