Silenseed Publishes Data on siRNA Delivery System, Plans for Phase II/III Cancer Study | GenomeWeb

Israeli RNAi drug developer Silenseed this week published in vitro and in vivo data demonstrating the potential of its implantable siRNA delivery system to knock down the oncogene KRAS as a treatment for pancreatic cancer.

Meanwhile, as it nears the completion of a phase I trial of its RNAi drug delivery platform — called Local Delivery of RNAi, or LODER — Silenseed is preparing to begin a multinational phase II/III study that could lay the groundwork for US regulatory approval, a company official told Gene Silencing News.

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