Silence Therapeutics this week announced that it has begun dosing patients in a phase Ib/IIa clinical trial of its cancer treatment Atu027 in combination with chemotherapy after having identified the drug’s maximum tolerated dose in a phase I study last year.

Also this week, Silence reported its 2012 financial results, posting a sharp increase in its operating loss due to a roughly £20.1 million ($30.2 million) impairment charge. Meanwhile, the company continues to weigh its options for its other pipeline programs in order to lower its dependence on Atu027.

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