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Sigma-Proligo Open Shop in France to Boost Oligo Production

NEW YORK (GenomeWeb News) — Sigma-Proligo, the RNAi and PCR division of Sigma-Aldrich, yesterday said it has opened offices near Paris.
The company said its newly acquired 2,000-square-foot facility in the Genopole d’Evry biopark will enable it to advance oligonucleotide production.
Sigma-Proligo specializes in nucleic acid synthesis and holds patents in siRNA gene silencing. Sigma-Aldrich’s operations manager Khalil Arar predicts the RNAi market has a compound annual growth rate of 14 percent, and expects the new facilities will help the company meet that new demand.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.