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Sigma-Aldrich: Oct 18, 2007

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Sigma-Aldrich has introduced the N-Ter nanoparticle siRNA transfection system.
 
According to the company, the system uses a stable nanoparticle, rather than a lipid-based transfection reagent, that is formed by combining siRNA with the N-Ter peptide.
 
"Traditional lipid-based siRNA transfection reagents exhibit a number of drawbacks, including high cell death rates and a limited ability to deliver siRNA into a variety of cell types, such as primary, neuronal, differentiated, and non-dividing cells," Tim Fleming, director of global commercial marketing at Sigma-Aldrich, said in a statement. "Our goal is to introduce a reagent into the scientific community that effectively bypasses these historic limitations and enables siRNA transfection to be performed in a wider variety of model systems."

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