A team of researchers from the Scripps Institute and Novartis this month reported new details about how small RNAs such as siRNAs and microRNAs interact with the RNA-induced silencing complex.

Specifically, the investigators found that highly complementary targets of small RNAs can accelerate the release of guide RNA from Argonaute2 by destabilizing RISC. This “unloading” activity can be further enhanced by mismatches between the target and the 5’ end of the RNA guide strand, but attenuated by mismatches to the 3’ end.

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In Science this week: issues in reproducibility, circulating DNA predicts breast cancer relapse, and more.

Because of an autoimmune disorder, a man has been shedding live polioviruses for 28 years, according to an analysis appearing in PLOS Pathogens.

Being in a long-term collaboration can increase researchers' citation rates by 17 percent, a recent analysis says.

By analyzing tweets, Canadian researchers examine the public's view of gene patenting.

Sep
10
Sponsored by
Qiagen

In this online seminar, Jo Vandesompele of the Center for Medical Genetics at Ghent University will discuss methods for improving the analysis of microRNA expression from a range of samples.