A team of researchers from the Scripps Institute and Novartis this month reported new details about how small RNAs such as siRNAs and microRNAs interact with the RNA-induced silencing complex.

Specifically, the investigators found that highly complementary targets of small RNAs can accelerate the release of guide RNA from Argonaute2 by destabilizing RISC. This “unloading” activity can be further enhanced by mismatches between the target and the 5’ end of the RNA guide strand, but attenuated by mismatches to the 3’ end.

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In Science this week: caution urged in use of gene drives, and more.

NIH's Sally Rockey examines the tapped and untapped potential of the NIH peer reviewer pool.

PLOS Biology has asked researchers how they envision the future of genetics and genomics.

Representative Lamar Smith brings back a provision to require the National Science Foundation to certify that each study it funds is "in the national interest."

Sep
10
Sponsored by
Qiagen

In this online seminar, Jo Vandesompele of the Center for Medical Genetics at Ghent University will discuss methods for improving the analysis of microRNA expression from a range of samples.