A team of researchers from the Scripps Institute and Novartis this month reported new details about how small RNAs such as siRNAs and microRNAs interact with the RNA-induced silencing complex.

Specifically, the investigators found that highly complementary targets of small RNAs can accelerate the release of guide RNA from Argonaute2 by destabilizing RISC. This “unloading” activity can be further enhanced by mismatches between the target and the 5’ end of the RNA guide strand, but attenuated by mismatches to the 3’ end.

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In Nature this week: association between genome-wide homozygosity and traits like height and cognitive ability, improved CRISPR-Cas9 editing, and more.

A survey examines how age, political leanings, and more influence how Americans view certain scientific topics, the Associated Press reports.

A researcher who pleaded guilty to making false statements in research reports has been sentenced to four and a half years in prison and must pay $7.2 million back to the NIH.

The BabySeq project to study the risks and benefits of sequencing newborns is underway.