RXi Pharmaceuticals said this week that, in collaboration with Miragen Therapeutics, it has generated positive in vitro data demonstrating the use of its self-delivering RNAi agents to enhance the activity of a particular microRNA.

Specifically, the companies used the self-delivering molecules to create an miRNA mimic capable of down-regulating a reporter gene whose expression is controlled by the microRNA in cell culture model systems developed by Miragen.

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