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Rosetta, Collaborators Report on microRNAs in Epithelial-Mesenchymal Transition

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Rosetta Genomics this week announced the publication of data demonstrating the involvement of certain microRNAs in epithelial-mesenchymal transition, or EMT, in cancers of unknown primary origin.

EMT is the acquisition of migratory, mesenchymal-like properties of epithelial cells, and is often associated with cancer metastasis.

According to the data, which appeared in Clinical & Translational Oncology, Rosetta and collaborators from the University of Ioannina studied the expression of 982 miRNAs in 68 cases of cancer of unknown primary origin.

They found that miR-203 and members of the miR-200 family were "consistently but non-significantly downregulated" in such cancers with the EMT phenotype.

"In view of the consistency of the observed levels of miR200 family expression by EMT status, more sensitive EMT-capturing technologies and larger [cancer of unknown primary origin] cohorts should be studied for further validation of these data," study co-author George Pentheroudakis said in a statement.

Rosetta currently markets an miRNA-based diagnostic for determining the source of cancers of unknown primary origin called the Rosetta Cancer Origin test.

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