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Rosetta, Collaborators Report on microRNAs in Epithelial-Mesenchymal Transition


Rosetta Genomics this week announced the publication of data demonstrating the involvement of certain microRNAs in epithelial-mesenchymal transition, or EMT, in cancers of unknown primary origin.

EMT is the acquisition of migratory, mesenchymal-like properties of epithelial cells, and is often associated with cancer metastasis.

According to the data, which appeared in Clinical & Translational Oncology, Rosetta and collaborators from the University of Ioannina studied the expression of 982 miRNAs in 68 cases of cancer of unknown primary origin.

They found that miR-203 and members of the miR-200 family were "consistently but non-significantly downregulated" in such cancers with the EMT phenotype.

"In view of the consistency of the observed levels of miR200 family expression by EMT status, more sensitive EMT-capturing technologies and larger [cancer of unknown primary origin] cohorts should be studied for further validation of these data," study co-author George Pentheroudakis said in a statement.

Rosetta currently markets an miRNA-based diagnostic for determining the source of cancers of unknown primary origin called the Rosetta Cancer Origin test.

The Scan

Guidelines for Ancient DNA Work

More than two dozen researchers have developed new ethical guidelines for conducting ancient DNA research, which they present in Nature.

And Cleared

A UK regulator has cleared former UK Prime Minister David Cameron in concerns he should have registered as a consultant-lobbyist for his work with Illumina, according to the Financial Times.

Suit Over Allegations

The Boston Globe reports that David Sabatini, who was placed on leave from MIT after allegations of sexual harassment, is suing his accuser, the Whitehead Institute, and the institute's director.

Nature Papers on Esophageal Cancer, Origin of Modern Horses, Exome Sequencing of UK Biobank Participants

In Nature this week: genetic and environmental influences of esophageal cancer, domestic horse origin traced to Western Eurasian steppes, and more.