Despite the promise of RNAi as a therapeutic, the road from the clinic to the marketplace for drugs based on the gene-silencing technology has proven to be a bumpy one with the failure of some of the field's earliest candidates.

Among the most notable is Opko Health's bevasiranib, an siRNA-based treatment for wet age-related macular degeneration that was the first drug of its kind to enter human testing and the first to reach the final phase of clinical development.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.