Alnylam Pharmaceuticals this week released new preclinical data on its GalNAc conjugate delivery technology, showing that the approach could permit subcutaneous delivery of siRNAs with a wide therapeutic index.

In light of these “highly promising” data, the company anticipates filing an investigational new drug application for a GalNAc-enabled version of its phase II TTR-mediated amyloidosis treatment ALN-TTR02 by year end.

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In PNAS this week: rare variants linked to bleeding disorder, comparison of whole-exome and whole-genome sequencing, and more.

George Church tells The Sunday Times that his group has inserted some woolly mammoth genes into elephant cells.

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