Alnylam Pharmaceuticals released this week details about its product-development and business goals for 2006, announcing, among other things, that it will add an additional RNAi-based drug to its formal pipeline and release non-human primate data from its systemic RNAi program.

Also this week, early RNAi mover CytRx released guidance for the year, showing that it continues to distance itself from the gene-silencing technology as a therapeutic modality by focusing on its newer small-molecule drug and DNA vaccine programs.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.