A little less than a year after it lost its partner for its preclinical hepatitis C therapy RG-101, Regulus Therapeutics announced last week that AstraZeneca has stepped away from the companies' program to develop an atherosclerosis drug targeting microRNA-33.

The firms will, however, continue to work together on drugs for metabolic diseases and cancer, and AstraZeneca retains the right to substitute a new target in lieu of miR-33 under their ongoing alliance.

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