Skip to main content
Premium Trial:

Request an Annual Quote

Regulus Preclinical Data Shows Liver Cancer Biomarker Potential of microRNAs

Premium

Regulus Therapeutics this week announced the presentation of preclinical data showing that circulating microRNAs may be effective biomarkers for determining tumor growth and systemic response disease in liver cancer.

The findings were released at this year's American Association for Cancer Research annual meeting.

Among Regulus' oncology efforts are programs focusing on miR-21 and miR-221, both of which have been linked to liver cancer. As part of its research in the area, the company looked at whether circulating miRNAs could act as disease biomarkers in a mouse model of the disease.

According to a poster presented at AACR, Regulus investigators found that deregulation of liver miRNA profiles increases with tumor size and that miRNAs in serum "reflect both changes in tumor tissues and systemic response to tumor burden."

Notably, most of the changes in both liver and serum are reversed upon inhibition of the driving oncogene — in the case of the animal models, HRAS.

"Thus, circulating microRNAs are promising candidates for tumor detection, as well as monitoring disease progression and treatment response," the scientists concluded in their poster.

The Scan

More Boosters for US

Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.

From a Pig

A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.

For Privacy's Sake

Wired reports that more US states are passing genetic privacy laws.

Science Paper on How Poaching Drove Evolution in African Elephants

In Science this week: poaching has led to the rapid evolution of tuskless African elephants.