NEW YORK (GenomeWeb) – Regulus Therapeutics announced last week that it has initiated a natural history of disease study, called ATHENA, in patients with Alport syndrome.

Alport syndrome is caused by mutations in three genes that affect production of the type IV collagen family of proteins. The result is a disruption to the structure of the glomerular basement membrane, increased expression of microRNA-21, an increase in fibrosis, and the loss of renal function, which ultimately leads to end-stage renal disease.

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The Jackson Laboratory has filed a complaint accusing Nanjing University of breeding and re-selling its mouse models, the Hartford Courant reports.

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