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Papers of Note for Feb 2009


The Effect of Tissue-Specific Promoters and microRNA Recognition Elements on Stability of Transgene Expression after Hydrodynamic Naked Plasmid DNA Delivery

Human Gene Therapy, Feb. 1, 2009 epub ahead of print
Sebestyen et al.

Biological Basis for Restriction of microRNA Targets to the 3' Untranslated Region in Mammalian mRNAs

Nature Structural & Molecular Biology, Feb. 1, 2009 epub ahead of print
Kay et al.

Forward RNAi Screens in Primary Human Hematopoietic Stem/Progenitor Cells

Blood, Feb. 2, 2009 epub ahead of print
Larsson et al.

Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure

Journal of Biomolecular Screening, Feb. 4, 2009 epub ahead of print
Brodin et al.

A RIG-I-Like RNA Helicase Mediates Antiviral RNAi Downstream of Viral siRNA Biogenesis in Caenorhabditis elegans

PLoS Pathogens, Feb. 6, 2009 epub ahead of print
Ding et al.

Antiviral Immunity in Drosophila Requires Systemic RNA Interference Spread

Nature, Feb. 8, 2009 epub ahead of print
Andino et al.

HIV-1 TAR miRNA Protects Against Apoptosis by Altering Cellular Gene Expression

Retrovirology, Feb. 16, 2009 epub ahead of print
Kashanchi et al.

Determination of Sample Size in Genome-Scale RNAi Screens

Bioinformatics, Feb. 17, 2009 epub ahead of print
Zhang & Heyse

Vectors Expressing Efficient RNA Decoys Achieve Long-Term Suppression of Specific microRNA Activity in Mammalian Cells

Nucleic Acids Research, Feb. 17, 2009 epub ahead of print
Iba et al.

A Genetic Screen for Components of the Mammalian RNA Interference Pathway in Bloom-Deficient Mouse Embryonic Stem Cells

Nucleic Acids Research, Feb. 17, 2009 epub ahead of print
Wang et al.

Increased RNAi is Related to Intracellular Release of siRNA Via a Covalently Attached Signal Peptide

RNA, Feb. 18, 2009 epub ahead of print
Sczakiel et al.

microPred: Effective Classification of Pre-miRNAs for Human miRNA Gene Prediction

Bioinformatics, Feb. 20, 2009 epub ahead of print
Batuwita & Palade

Abrogation of DNA Vector-Based RNAi During Apoptosis in Mammalian Cells Due to Caspase-Mediated Cleavage and Inactivation of Dicer-1

Cell Death and Differentiation, Feb. 20, 2009 epub ahead of print
Shah et al.

Subnuclear Compartmentalization of Transiently Expressed Polyadenylated pri-microRNAs: Processing at Transcription Sites or Accumulation in SC35 Foci

Cell Cycle, Feb. 21, 2009 epub ahead of print
Pawlicki & Steitz

Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support

Circulation, Feb. 23, 2009 epub ahead of print
Dorn et al.

Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

Circulation, Feb. 23, 2009 epub ahead of print
Poller et al.

Confirming the RNAi-Mediated Mechanism of Action of siRNA-Based Cancer Therapeutics in Mice

Journal of Clinical Investigation
, Feb. 23, 2009 epub ahead of print
Maclachlan et al.

Enhancement of Topical siRNA Delivery and Expression by Low-Fluence Erbium:YAG Laser Pretreatment of Skin

Human Gene Therapy
, Feb. 24, 2009 epub ahead of print
Fang et al.

Non-Allele-Specific Silencing of Mutant and Wildtype Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

Molecular Therapy, Feb. 24, 2009 epub ahead of print
Davidson et al.

2'-O-Methylation Stabilizes Piwi-Associated Small RNAs and Ensures DNA Elimination in Tetrahymena

RNA, Feb. 24, 2009 epub ahead of print
Kurth & Mochizuki

Single-Vector Inducible Lentiviral RNAi System for Oncology Target Validation

Cell Cycle, Feb. 25, 2009 epub ahead of print
Benson et al.

Circulating microRNAs, Potential Biomarkers for Drug-Induced Liver Injury

Proceedings of the National Academy of Sciences, Feb. 25, 2009 epub ahead of print
Galas et al.

A Method for Detecting and Preventing Negative RNA Interference in Preparation of Lentiviral Vectors for siRNA Delivery

RNA, Feb. 25, 2009 epub ahead of print
Wong-Staal et al.

Molecular Evolution of a Viral Non-Coding Sequence Under the Selective Pressure of amiRNA-Mediated Silencing

PLoS Pathogens, Feb. 27, 2009 epub ahead of print
Chua et al.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.