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Recent RNAi-Related Papers of Note: Sep 23, 2005

Recent RNAi-Related Deals of Note
Protein Kinase C (Varepsilon) Is a Predictive Biomarker of Aggressive Breast Cancer and a Validated Target for RNA Interference Anticancer Therapy Cancer Research, Sept. 15, 2005; 65: 18, 8366-8371 Pan et al.
Developing an Effective RNA Interference Strategy Against a Plus-Strand RNA Virus: Silencing of Coxsackievirus B3 and Its Cognate Coxsackievirus-Adenovirus Receptor Biological Chemistry, Sept. 2005; 386: 9, 857-863 Kurreck et al.
Complete Cure of Persistent Virus Infections by Antiviral siRNAs Molecular Therapy, Sept. 9, 2005; epub ahead of print Colbère-Garapin et al.
Uncovering RNAi Mechanisms in Plants: Biochemistry Enters the Foray FEBS Letters, Sept. 8, 2005;
epub ahead of print
Hannon et al.
Antiviral Silencing in Animals FEBS Letters, Sept. 8, 2005;
epub ahead of print
Ding and Li
Absence of Non-Specific Effects of RNA Interference Triggered by Long Double-Stranded RNA in Mouse Oocytes Developmental Biology, Sept. 8, 2005; epub ahead of print Schultz et al.
Identification and Characterization of Small RNAs Involved in RNA Silencing FEBS Letters, Sept. 6, 2005;
epub ahead of print
Tuschl and Aravin
Genome-Wide Application of RNAi to the Discovery of Potential Drug Targets. FEBS Letters, Sept. 6, 2005;
epub ahead of print
Taira et al.
Therapeutic Inhibition of Hepatitis B Virus Surface Antigen Expression by RNA Interference Biochemical and Biophysical Research Communications, Sept. 6, 2005; epub ahead of print Chang et al.
Efficient Delivery of RNA Interference Effectors via In Vitro-Packaged SV40 Pseudovirions Human Gene Therapy, Sept. 2005; 16: 9, 1110-1115 Gottesman et al.
LIS1 RNA Interference Blocks Neural Stem Cell Division, Morphogenesis, and Motility at Multiple Stages Journal of Cell Biology, Sept. 12, 2005; 170: 6, 935-945 Vallee et al.
TRBP, a Regulator of Cellular PKR and HIV-1 Virus Expression, Interacts with Dicer and Functions in RNA Silencing EMBO Reports, Sept. 2, 2005; epub ahead of print Filipowicz et al.
A Lentiviral MicroRNA-Based System for Single-Copy Polymerase II-Regulated RNA Interference in Mammalian Cells Proceedings of the National Academy of Sciences, Sept. 13, 2005; 102: 37, 13212-13217 Elledge et al.
A Strategy for Probing the Function of Non-Coding RNAs Finds a Repressor of NFAT Science, Sept. 2, 2005; 309: 5740, 1570-1573 Schultz et al.
DICER-LIKE 4 Functions in Trans-Acting Small Interfering RNA Biogenesis and Vegetative Phase Change in Arabidopsis thaliana Proceedings of the National Academy of Sciences, Sept. 6, 2005; 102: 36, 12984-12989 Carrington et al.
A microRNA Cluster as a Target of Genomic Amplification in Malignant Lymphoma Leukemia, Sept. 15, 2005; epub ahead of print Seto and Tagawa
Mesodermally Expressed Drosophila microRNA-1 is Regulated by Twist and is Required in Muscles During Larval Growth Genes & Development, Sept. 15, 2005; epub ahead of print Ambros and Sokol
Computational Evidence for Hundreds of Non-Conserved Plant microRNAs BMC Genomics, Sept. 13, 2005; 6: 1, 119 Krogh and Lindow
The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans Developmental Cell, Sept. 2005; 9: 3, 403-414 Ambros et al.
The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.