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Recent Key Deals Between RNAi Drug Developers and Big Pharma/Biotech

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Eli Lilly management last week highlighted the most promising drug candidates in the company’s pipeline, including two antisense-based drugs currently in the clinic for cancer (see related story, this issue). Despite Lilly’s early look at the RNAi field though its now-expired 2004 collaboration with Sirna Therapeutics, the drugs giant has yet to embrace RNAi as a therapeutic modality.
 
Other big players in the pharmaceutical, biotech, and medical device fields, however, have taken steps to incorporate RNAi into their drug-development efforts. Below is a snapshot of key alliances between big pharma/biotech and RNAi firms.
 

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.