This article has been updated from a previous version to clarify Quark's licensing agreement for the structure of AKIi-5 with Silence Therapeutics.
 
Quark Pharmaceuticals this week announced that it has begun dosing patients in a phase I trial of AKLi-5, an siRNA-based treatment for acute renal failure, marking what the company said is the first time a systemic RNAi-based drug has been administered to humans (see sidebar below).

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