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In Print: Last Month's RNAi- and microRNA-Related Papers of Note: Sep 13, 2012

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Toxicological and Pharmacokinetic Properties of Chemically Modified siRNAs Targeting p53 RNA Following Intravenous Administration

Nucleic Acids Research Aug, 2012; 22: 4, 255-264
Erlich et al.


Optimized PCR Conditions and Increased shRNA Fold Representation Improve Reproducibility of Pooled shRNA Screens

PLoS One, Aug. 1, 2012; epub ahead of print
Vermeulen et al.


PDX-1 is a Therapeutic Target for Pancreatic Cancer, Insulinoma, and Islet Neoplasia Using a Novel RNA Interference Platform

PLoS One, Aug. 8, 2012; epub ahead of print
Brunicardi et al.


Molecular Dynamics Simulations of Ago Silencing Complexes Reveals a Large Repertoire of Admissible Seed-Less Targets

Scientific Reports, Aug. 10, 2012; epub
Zhou et al.


Dicer is Required for Proliferation, Viability, Migration, and Differentiation in Corticoneurogenesis

Neuroscience, Aug. 13, 2012; epub ahead of print
Davidson et al.


A Novel RNAI Protein, Dsh1, Assembles RNAi Machinery on Chromatin to Amplify Heterochromatic siRNA

Genes & Development, Aug. 15, 2012; 26: 16, 1811-1824
Murakami et al.


Respiratory Syncytial Virus Modifies microRNAs Regulating Host Genes which Affect Virus Replication

Journal of General Virology, Aug. 15, 2012; epub ahead of print
Tripp et al.


Efficacy of a Novel Class of RNA Interference Therapeutic Agents

PLoS One, Aug. 15, 2012; epub ahead of print
Ohgi et al.


The Slicing Activity of miRNA-Specific Argonautes is Essential for the miRNA Pathway in C. elegans

Nucleic Acids Research, Aug. 16, 2012; epub ahead of print
Bouasker & Simard


Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

PLoS Pathogens, Aug. 16, 2012; epub ahead of print
van Rij et al.


Functional Selection of shRNA Loops from Randomized Retroviral Libraries

PLoS One, Aug. 17, 2012; epub ahead of print
Bramsen et al.


Single-Stranded microRNA Mimics

RNA, Aug. 21, 2012; epub ahead of print
Lim et al.


Dicer-Dependent and -Independent Argonaute2 Protein Interaction Networks in Mammalian Cells

Molecular & Cellular Proteomics, Aug. 23, 2012; epub ahead of print
Meister et al.


The Novel MER Transposon-Derived miRNAs in Human Genome

Gene, Aug. 25, 2012; epub ahead of print
Kim et al.


Identification of a Two-Layer Regulatory Network of Proliferation-Related microRNAs in Hepatoma Cells

Nucleic Acids Research, Aug. 25, 2012; epub ahead of print
Chou et al.


Small Interfering RNA-Producing Loci in the Ancient Parasitic Eukaryote Trypanosoma brucei

BMC Genomics, Aug. 27, 2012; epub ahead of print
Ullu et al.


microRNA Profiling of Diagnostic Needle Aspirates from Patients with Pancreatic Cancer

British Journal of Cancer, Aug. 28, 2012; epub ahead of print
Philip et al.


Circulating microRNAs in Plasma as Early Detection Markers for Breast Cancer

International Journal of Cancer, Aug. 28, 2012; epub ahead of print
Burwinkel et al.


Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Cell, Aug. 31, 2012; 150: 5, 895-908
Corey et al.


Single-Stranded siRNAs Activate RNAi in Animals

Cell, Aug. 31, 2012; 150: 5, 883-894
Crooke et al.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.