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In Print: Last Month's RNAi- and microRNA-Related Papers of Note: Feb 2, 2012

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Branched, Tripartite-Interfering RNAs Silence Multiple Target Genes with Long Guide Strands

Nucleic Acid Therapeutics, Jan. 5, 2012; epub ahead of print
Lee et al.


An Optimized Sponge for microRNA miR-9 Affects Spinal Motor Neuron Development In Vivo

Frontiers in Neuroscience, Jan. 5, 2012; epub ahead of print
Sun et al.


Enhanced Intracellular Delivery and Multi-Target Gene Silencing Triggered by Tripodal RNA Structures

Journal of Gene Medicine, Jan. 6, 2012; epub ahead of print
Lee et al.


Rapid Generation of microRNA Sponges for microRNA Inhibition

PLoS One, Jan. 6, 2012; epub ahead of print
van den Berg et al.


The N Domain of Argonaute Drives Duplex Unwinding During RISC Assembly

Nature Structural & Molecular Biology, Jan. 10, 2012; epub ahead of print
Kwak & Tomari


Evolution of Susceptibility to Ingested Double-Stranded RNAs in Caenorhabditis Nematodes

PLoS One, Jan. 11, 2012; epub ahead of print
Nuez & Felix


Host Gene Targets for Novel Influenza Therapies Elucidated by High-Throughput RNA Interference Screens

FASEB Journal, Jan. 12, 2012; epub ahead of print
Tripp et al.


mRNA Knockdown by Single-Strand RNA is Improved by Chemical Modifications

Nucleic Acids Research, Jan. 16, 2012; epub ahead of print
Willingham et al.


A Potent 2'-O-Methylated RNA-Based microRNA Inhibitor with Unique Secondary Structures

Nucleic Acids Research, Jan. 17, 2012; epub ahead of print
Iba et al.


Microparticles: Major Transport Vehicles for Distinct miRNAs in Circulation

Cardiovascular Research, Jan. 18, 2012; epub ahead of print
Peter et al.


Biogenesis of Mammalian microRNAs by a Non-Canonical Processing Pathway

Nucleic Acids Research, Jan. 23, 2012; epub ahead of print
Hastings et al.


Amplified microRNA Detection by Templated Chemistry

Nucleic Acids Research, Jan. 25, 2012; epub ahead of print
Harcourt & Kool


Amino-Modified and Lipid-Conjugated Dicer-Substrate siRNA Enhances RNAi Efficacy

Bioconjugate Chemistry, Jan. 26, 2012; epub ahead of print
Seyama et al.


The Viral and Cellular microRNA Targetome in Lymphoblastoid Cell Lines

PLoS Pathogens, Jan. 26, 2012; epub ahead of print
Cullen et al.


A Delivery System Targeting Bone Formation Surfaces to Facilitate RNAi-Based Anabolic Therapy

Nature Medicine, Jan. 29, 2012; epub ahead of print
Qin et al.


Widespread RNA 3'-End Oligouridylation in Mammals

RNA, Jan. 30, 2012; epub ahead of print
McManus et al.


Defined Folate-PEG-siRNA Conjugates for Receptor-Specific Gene Silencing

Molecular Therapy — Nucleic Acids, Jan. 31, 2012; epub ahead of print
Wagner et al.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.