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In Print: Last Month's RNAi- and microRNA-Related Papers of Note: Feb 14, 2013


The 5' Binding MID Domain of Human Argonaute 2 Tolerates Chemically Modified Nucleotide Analogues

Nucleic Acid Therapeutics, Jan. 5, 2013; epub ahead of print
Damha et al.

Therapeutic Effects of microRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression

Molecular Therapy, Jan. 8, 2013; epub ahead of print
Ochiya et al.

pH-Triggered Nanoparticle-Mediated Delivery of siRNA to Liver Cells In Vitro and In Vivo

Bioconjugate Chemistry, Jan. 10, 2013; epub ahead of print
Miller et al.

An Analysis and Validation Pipeline for Large-Scale RNAi-Based Screens

Scientific Reports, Jan. 16, 2013; epub ahead of print
Church et al.

Derepression of a Neuronal Inhibitor Due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion

Cell, Jan. 17, 2013; 152: 262-275
Gogos et al.

Rat miR-155 Generated from the lncRNA Bic is 'Hidden' in the Alternate Genomic Assembly and Reveals the Existence of Novel Mammalian miRNAs and Clusters

RNA, Jan. 17, 2013; epub ahead of print
Masotti et al.

Deep Sequencing of Small RNAs Identifies Canonical and Non-Canonical miRNA and Endogenous siRNAs in Mammalian Somatic Tissues

Nucleic Acids Research, Jan. 15, 2013; epub ahead of print
Castellano & Stebbing

Inactivation of the microRNA-183/96/182 Cluster Results in Syndromic Retinal Degeneration

Proceedings of the National Academy of Sciences, Jan. 22, 2013; epub ahead of print
Xu et al.

Identification of microRNAs in Calcisponges: Independent Evolution of microRNAs in Basal Metazoans

Journal of Experimental Zoology, Jan. 24, 2013; epub ahead of print
Peterson et al.

On Measuring miRNAs after Transient Transfection of Mimics or Antisense Inhibitors

PLoS One, Jan. 24, 2013; epub ahead of print
Goodall et al.

GATA3 Suppresses Metastasis and Modulates the Tumor Microenvironment by Regulating microRNA-29b Expression

Nature Cell Biology, Jan. 27, 2013; epub ahead of print
Werb et al.

First-in-Man Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

Cancer Discovery, Jan. 28, 2013; epub ahead of print
Burris et al.

Neutral Polymeric Micelles for RNA Delivery

Bioconjugate Chemistry, Jan. 29, 2013; epub ahead of print
Stayton et al.

Surface Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition

Biomacromolecules, Jan. 29, 2013; epub ahead of print
Mixson et al.

Structural Insights into RISC Assembly Facilitated by dsRNA-Binding Domains of Human RNA Helicase A

Nucleic Acids Research, Jan. 29, 2013; epub ahead of print
Fu & Yuan et al.

High-Throughput Sequencing Reveals Extraordinary Fluidity of miRNA, piRNA, and siRNA Pathways in Nematodes

Genome Research, Jan. 30, 2013; epub ahead of print
Ruvkun et al.

Tsw Gene-Based Resistance is Triggered by a Functional RNA Silencing Suppressor Protein of the Tomato Spotted Wilt Virus

Molecular Plant Pathology, Jan. 30, 2013; epub ahead of print
Kormelink et al.

Single-Cell microRNA Analysis Using Microfluidic Flow Cytometry

PloS One, Jan. 30, 2013; epub ahead of print
Singh et al.

Identification of Small RNA Pathway Genes Using Patterns of Phylogenic Conservation and Divergence

Nature, Jan. 31, 2013; epub ahead of print
Ruvkun et al.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.