Phase I Data Shows RXi Anti-Scarring Drug Safe, Well-tolerated | GenomeWeb

RXi Pharmaceuticals this week announced that its lead drug candidate, the anti-scarring agent RXI-109, was safe and well tolerated in a phase I study, while producing a dose-dependent reduction of its target protein.

RXI-109 comprises siRNAs designed to inhibit connective tissue growth factor, or CTGF, a protein linked to wound healing and other fibrotic processes. It employs the company's proprietary self-delivering technology, which enables cellular uptake without the need for a delivery vehicle.

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

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In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.