By Doug Macron

Pfizer has stepped back from its goal of filing an investigational new drug application on an internally developed RNAi drug by the end of next year as it evaluates alternative technologies, Gene Silencing News has learned.

The big pharma's Research Technology Center still anticipates filing an IND before the end of 2011, but now expects it to be for "an in-house nucleic acid drug" in 2011, rather than one necessarily based on RNAi.

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The partially reinstated US travel ban leaves space for uncertainty for researchers, Nature News says.

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In PNAS this week: DNA methylation profiles of tumor tissue, gene dynamics in prokaryotes, and more.