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Peter Buckel, Sigma-Aldrich, Dharmacon

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People in the News

Peter Buckel has stepped down as CEO of Atugen following the company's recent acquisition by UK-based SR Pharma.

Buckel joined Atugen early last year (see RNAi News, 4/23/2004) after serving as CEO of Xantos Biomedicine, a company he co-founded. Prior to this, he was senior vice president of molecular medicine for Roche Diagnostics.

Products & Services

Sigma-Aldrich said this week that it is offering its Mission TRC shRNA library as purified plasmid DNA. This is in addition to the frozen bacterial glycerol stock format the company currently offers.

Sigma-Aldrich said it is offering the library in the new format through an exclusive arrangement with The Broad Institute's RNAi Consortium.

The consortium — which was designed to create a library of RNAi molecules against virtually all human and mouse genes — includes six research institutions: Massachusetts General Hospital, Harvard Medical School, Dana-Farber Cancer Institute, The Broad Institute, Whitehead Institute for Biomedical Research, and the Massachusetts Institute of Technology.

Other members include five life science organizations: Bristol-Myers Squibb, Eli Lilly, Novartis, Sigma-Aldrich, and the Taiwan government-sponsored academic Academia Sinica-National Science Council. Each of these member organizations will contribute $3.6 million over three years to support the consortium, the Broad Institute stated.


Dharmacon said this week that it has released a human genome-wide siRNA library.

According to Dharmacon, the library includes more than 100,000 siRNA reagents targeting over 21,000 human genes contained in the NCBI RefSeq database. A Smartpool siRNA reagent and four individual siRNAs are available for each human gene, the company noted.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.