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Papers of Note: Aug 4, 2011

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RNAi- and microRNA-Related Papers Published July 2011

Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers

Journal of Nucleic Acids, July 12, 2011; epub ahead of print
Tsujimoto et al.


Small Interfering RNAs Targeting Cyclin D1 and Cyclin D2 Enhance the Cytotoxicity of Chemotherapeutic Agents in Mantle Cell Lymphoma Cell Lines

Leukemia & Lymphoma, July 12, 2011; epub ahead of print
Chen et al.


Synergistic Silencing: Combinations of Lipid-Like Materials for Efficacious siRNA Delivery

Molecular Therapy, July 12, 2011; epub ahead of print
Anderson et al.


microRNA Regulation of Intestinal Epithelial Tight Junction Permeability

Gastroenterology, July 13, 2011; epub ahead of print
Ma et al.


Dicer Recognizes the 5' End of RNA for Efficient and Accurate Processing

Nature, July 13, 2011; 475: 7355, 201-205
Kim et al.


Functional Genomics Reveal that the Serine Synthesis Pathway is Essential in Breast Cancer

Nature, July 14, 2011; epub ahead of print
Sabatini et al.


Both piRNA and siRNA Pathways are Silencing Transcripts of the Suffix Element in the Drosophila melanogaster Germline and Somatic Cells

PLoS One, July 14, 2011; epub ahead of print
Tchurikov & Kretova


Diagnostic and Prognostic Signatures from the Small Non-Coding RNA Transcriptome in Prostate Cancer

Oncogene, July 18, 2011; epub ahead of print
Jenster et al.


Expression of Multiple Artificial microRNAs from a Chicken miRNA-126-Based Lentiviral Vector

PLoS One, July 18, 2011; epub ahead of print
Chen et al.


Constitutive Expression of shRNA In Vivo Triggers Build Up of Mature Hairpin Molecules

Human Gene Therapy, July 22, 2011; epub ahead of print
Morral et al.


Effective Delivery of Anti-miRNA DNA Oligonucleotides by Functionalized Gold Nanoparticles

Journal of Biotechnology, July 22, 2011; epub ahead of print
Bae et al.


siRNA-Eluting Surfaces as a Novel Concept for Intravascular Local Gene Silencing

Molecular Medicine, July 22, 2011; epub ahead of print
Wendel et al.


The microRNA miR-29 Controls Innate and Adaptive Immune Responses to Intracellular Bacterial Infection by Targeting Interferon Gamma

Nature Immunology, July 24, 2011; epub ahead of print
Cao et al.


A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Cell, July 27, 2011; epub ahead of print
Pandolfi et al.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.