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Papers of Note: May 5, 2011

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RNAi- and microRNA-Related Papers Published April 2011

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

Cell, April 1, 2011; 145: 1, 145-158
Lowe et al.


Establishment and Characterization of Prnp Knockdown Neuroblastoma Cells Using Dual microRNA-Mediated RNA Interference

Prion, April 1, 2011; epub ahead of print
Yoo et al.


RNAi-Mediated Gene Silencing in Tumor Tissue Using Replication-Competent Retroviral Vectors

Gene Therapy, April 7, 2011; epub ahead of print
Buchholz et al.


AAV-Mediated In Vivo Knockdown of Luciferase Using Combinatorial RNAi and U1i

Gene Therapy, April 7, 2011; epub ahead of print
Ritsema et al.


microRNA Dysregulation Following Spinal Cord Contusion: Implications for Neural Plasticity and Repair

Neuroscience, April 7, 2011; epub ahead of print
Miranda et al.


SID-1 is a dsRNA-Selective ds-RNA-Gated Channel

RNA, April 7, 2011; epub ahead of print
Shih & Hunter


Combinatorial Effects of microRNAs to Suppress the Myc Oncogenic Pathway

Blood, April 8, 2011; epub ahead of print
Malumbres et al.


Reversible Suppression of an Essential Gene in Adult Mice Using Transgenic RNA Interference

Proceedings of the National Academy of Sciences, April 11, 2011; epub ahead of print
Lowe et al.


Analysis of microRNA Signatures Using Size-Coded Ligation-Mediated PCR

Nucleic Acids Research, April 12, 2011; epub ahead of print
Faridani et al.


Multiple Targets of miR-302 and miR-372 Promote Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells

Nature Biotechnology, April 13, 2011; epub ahead of print
Blelloch et al.


An Effective Gene Knockdown Using Multiple shRNA-Expressing Adenovirus Vectors

Journal of Controlled Release, April 14, 2011; epub ahead of print
Mizuguchi et al.


Potent and Systematic RNAi-Mediated Gene Silencing with Single-Oligonucleotide Compounds

RNA, April 14, 2011; epub ahead of print
Samarsky et al.


A Comparison of Multiple shRNA-Expression Methods for Combinatorial RNAi

Genetic Vaccines and Therapy, April 17, 2011; epub ahead of print
Fanning et al.


Differential microRNA Regulation of HLA-C Expression and Its Association with HIV Control

Nature, April 17, 2011; epub ahead of print
Carrington et al.


Identification of miR-193b Targets in Breast Cancer Cells and Systems Biological Analysis of Their Functional Impact

Molecular & Cellular Proteomics, April 21, 2011; epub ahead of print
Perala et al.


Identification of piRNAs in the Central Nervous System

RNA, April 22, 2011; epub ahead of print
Kosik et al.


p53 Regulates Epithelial-Mesenchymal Transition Through microRNAs Targeting ZEB1 and ZEB2

Journal of Experimental Medicine, April 25, 2011; epub ahead of print
Croce et al.


Precursor miR-886, a Novel Non-Coding RNA Repressed in Cancer, Associates with PKR and Modulates its Activity

RNA, April 25, 2011; epub ahead of print
Lee et al.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.