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Papers of Note: Jan 13, 2011

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RNAi- and microRNA-Related Papers Published December 2010

Synthesis of Modified siRNA Bearing C-5 Polyamine-Substituted Pyrimidine Nucleoside in Their 3'-Overhang Regions and Its RNAi Activity

Bioorganic & Medicinal Chemistry Letters, Dec. 5, 2010; epub ahead of print
Ozaki et al.


Comparative Analysis of Non-Autonomous Effects of tasiRNAs and miRNAs in Arabidopsis thaliana

Nucleic Acids Research, Dec. 5, 2010; epub ahead of print
Weigel et al.


Cell Stress is Related to Re-Localization of Argonaute 2 and to Decreased RNA Interference in Human Cells

Nucleic Acids Research, Dec. 8, 2010; epub ahead of print
Sczakiel et al.


Design of Small Molecule-Responsive microRNAs Based on Structural Requirements for Drosha Processing

Nucleic Acids Research, Dec. 11, 2010; epub ahead of print
Smolke et al.


Repression of the miR-143/145 Cluster by Oncogenic Ras Initiates a Tumor-Promoting Feed-Forward Pathway

Genes & Development, Dec. 15, 2010; 24: 24, 2754-2759
Mendell et al.


siRNAs Targeted at Anti-Apoptotic mRNAs Increase Keratinocytes Sensitivity to Apoptosis

British Journal of Dermatology, Dec. 16, 2010; epub ahead of print
Avni et al.


Patterning of Gene Expression Using New Photolabile Groups Applied to Light-Activated RNA

Journal of the American Chemical Society, Dec. 16, 2010; epub ahead of print
Friedman et al.


A Transient Transgenic RNAi Strategy for Rapid Characterization of Gene Function During Embryonic Development

PLoS One, Dec. 16, 2010; 5: 12, e14375
Beier et al.


Polymer-Related Off-Target Effects in Non-Viral siRNA Delivery

Biomaterials, Dec. 21, 2010; epub ahead of print
Kissel et al.


microRNA-Regulated, Systemically Delivered rAAV9: a Step Closer to CSN-Restricted Transgene Expression

Molecular Therapy, Dec. 21, 2010; epub ahead of print
Gao et al.


Unexpected Origins of the Enhanced Pairing Affinity of 2'-Fluoro-Modified RNA

Nucleic Acids Research, Dec. 22, 2010; epub ahead of print
Egli et al.


Widespread Regulatory Activity of Vertebrate microRNA* Species

RNA, Dec. 22, 2010; epub ahead of print
Lai et al.


A Mammalian Functional-Genetic Approach to Characterizing Cancer Therapeutics

Nature Chemical Biology, Dec. 26, 2010; epub ahead of print
Hemann et al.


miR-499 Regulates Mitochondrial Dynamics by Targeting Calcineurin and Dynamin-Related Protein-1

Nature Medicine, Dec. 26, 2010; epub ahead of print
Li et al.


miR-29 and miR-30 Regulate B-Myb Expression During Cellular Senescence

Proceedings of the National Academy of Sciences, Dec. 27, 2010; epub ahead of print
Dimaio et al.


Nanoparticle-Mediated Delivery of siRNA Targeting Parp1 Extends Survival of Mice Bearing Tumors Derived from Brca1-Dependent Ovarian Cancer Cells

Proceedings of the National Academy of Sciences, Dec. 27, 2010; epub ahead of print
Sharp et al.


Development of Quantitative Molecular Clinical Endpoints for siRNA Clinical Trials

Journal of Investigative Dermatology, Dec. 30, 2010; epub ahead of print
Kaspar et al.

The Scan

Highly Similar

Researchers have uncovered bat viruses that are highly similar to SARS-CoV-2, according to Nature News.

Gain of Oversight

According to the Wall Street Journal, the Biden Administration is considering greater oversight of gain-of-function research.

Lasker for mRNA Vaccine Work

The Scientist reports that researchers whose work enabled the development of mRNA-based vaccines are among this year's Lasker Award winners

PLOS Papers on Causal Variant Mapping, Ancient Salmonella, ALK Fusion Test for NSCLC

In PLOS this week: MsCAVIAR approach to map causal variants, analysis of ancient Salmonella, and more.