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Papers of Note: Apr 8, 2010

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RNAi- and microRNA-Related Papers Published March 2010

A Modified Feeding RNAi Method for Simultaneous Knockdown of More than One Gene in Caenorhabditis elegans

Biotechniques, March 2010; 48: 3, 229-232
Lee et al.


Distinct RNA-Dependent RNA Polymerases are Required for RNAi Triggered by Double-Stranded RNA Versus Truncated Transgenes in Paramecium tetraurelia

Nucleic Acids Research, March 3, 2010; epub ahead of print
Simon et al.


Gene Silencing Efficacy of siRNA-PEG Conjugates: Effects of PEGylation Site and PEG Molecular Weight

Journal of Controlled Release, March 4, 2010; epub ahead of print
Park et al.


Stc1: A Critical Link Between RNAi and Chromatin Modification Required for Heterochromatin Integrity

Cell, March 5, 2010; 140: 5, 666-677
Allshire et al.


The Tetrahymena Argonaute-Binding Protein Giw1p Directs a Mature Argonaute-siRNA Complex to the Nucleus

Cell, March 5, 2010; 140: 5, 692-703
Mochizuki et al.


A miR-21 Hairpin Structure-Based Gene Knockdown Vector

Biochemical and Biophysical Research Communications, March 11, 2010; epub ahead of print
Penmatsa et al.


Efficient Inhibition of miR-155 Function In Vivo by Peptide Nucleic Acids

Nucleic Acids Research, March 11, 2010; epub ahead of print
Vigorito et al.


The Peripheral Blood Mononuclear Cell microRNA Signature of Coronary Artery Disease

Biochemical and Biophysical Research Communications, March 15, 2010; epub ahead of print
Biessen et al.


Systematic Analysis of Off-Target Effects in an RNAi Screen Reveals microRNAs Affecting Sensitivity to TRAIL-Induced Apoptosis

BMC Genomics, March 15, 2010; epub ahead of print
Dunham et al.


Recognition of siRNA Asymmetry by TAR RNA Binding Protein

Biochemistry, March 17, 2010; epub ahead of print
Walton et al.


Functional Delivery of Viral miRNAs Via Exosomes

Proceedings of the National Academy of Sciences, March 18, 2010; epub ahead of print
Middeldorp et al.


Comparative Studies of Various Artificial microRNA Expression Vectors for RNAi in Mammalian Cells

Molecular Biotechnology, March 19, 2010; epub ahead of print
Guo et al.


Suppression of microRNA Accumulation via RNA Interference in Arabidopsis thaliana

Plant Molecular Biology, March 19, 2010; epub ahead of print
Jones et al.


Evidence of RNAi in Humans from Systemically Administered siRNA via Targeted Nanoparticles

Nature, March 21, 2010; epub ahead of print
Ribas et al.


Single-Nucleotide Polymorphisms Inside microRNA Target Sites Influence Tumor Susceptibility

Cancer Research, March 23, 2010; epub ahead of print
Calin et al.


Validation of a microRNA-Based qRT-PCR Test for Accurate Identification of Tumor Tissue Origin

Modern Pathology, March 26, 2010; epub ahead of print
Aharonov et al.


Reduced Seed Region-Based Off-Target Activity with Lentivirus-Mediated RNAi

RNA, March 26, 2010; epub ahead of print
Cleary et al.


Differential Regulation of microRNA Stability

RNA, March 26, 2010; epub ahead of print
Kiledjian et al.


Detection of Circulating Tumor Cells in Peripheral Blood from Patients with Gastric Cancer Using microRNA as a Marker

Journal of Molecular Medicine, March 28, 2010; epub ahead of print
Xiao et al.


Therapeutic Silencing of miR-10b Inhibits Metastasis in a Mouse Mammary Tumor Model

Nature Biotechnology, March 28, 2010; epub ahead of print
Weinberg et al.


Secretory Mechanisms and Intracellular Transfer of microRNAs in Living Cells

Journal of Biological Chemistry, March 30, 2010; epub ahead of print
Ochiya et al.


Dicer's Helicase Domain is Required for Accumulation of Some, But Not All, C. elegans Endogenous siRNAs

RNA, March 30, 2010; epub ahead of print
Bass et al.


In Vivo Trans-Specific Gene Silencing in Fungal Cells by In Planta Expression of Double-Stranded RNA

BMC Biology, March 31, 2010; epub ahead of print
Aragao et al.

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.