By Doug Macron

Although it bills itself primarily as an ophthalmic drug and instrumentation company, Opko Health has long been focused on the development of siRNA-based therapeutics, including the wet age-related macular degeneration treatment bevasiranib.

But with the failure of that drug in a phase III trial, Opko has lately been making investments in other technologies in earnest, raising questions about how much longer RNAi will remain as the centerpiece of the company's drug-development portfolio.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.