By Doug Macron

Although it bills itself primarily as an ophthalmic drug and instrumentation company, Opko Health has long been focused on the development of siRNA-based therapeutics, including the wet age-related macular degeneration treatment bevasiranib.

But with the failure of that drug in a phase III trial, Opko has lately been making investments in other technologies in earnest, raising questions about how much longer RNAi will remain as the centerpiece of the company's drug-development portfolio.

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