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One RNAi-Related Patent Application Published by the US Patent Office


Title: Method of Introducing siRNA into Adipocytes. Number: 20050014264. Filed: Dec. 11, 2003. Lead Inventor: Michael Czech, University of Massachusetts Medical School (CytRx Laboratories).

“In general, it has been difficult to introduce nucleic acid sequences into adipocytes,” the patent application’s abstract states. “Methods are described [in the application] for introducing nucleic acids such as siRNAs into adipocytes, including the introduction of sequences targeting Akt1, Akt2 and Myo1c. Methods for identifying genes involved in glucose transport and for identifying insulin response modulators are described [as are] … therapeutic methods,” the abstract notes.


The Scan

Vaccine Update Recommended

A US Food and Drug Administration panel recommends booster vaccines be updated to target Omicron, CNBC reports.

US to Make More Vaccines for Monkeypox Available

The US is to make nearly 300,000 vaccine doses available in the coming weeks to stem the spread of human monkeypox virus, according to NPR.

Sentence Appealed

The Associated Press reports that Swedish prosecutors are appealing the sentence given to a surgeon once lauded for transplanting synthetic tracheas but then convicted of causing bodily harm.

Genome Biology Papers on COVID-19 Effector Genes, Virtual ChIP-seq, scDART

In Genome Biology this week: proposed COVID-19 effector genes, method to predict transcription factor binding patterns, and more.