Title: Method of Introducing siRNA into Adipocytes. Number: 20050014264. Filed: Dec. 11, 2003. Lead Inventor: Michael Czech, University of Massachusetts Medical School (CytRx Laboratories).
“In general, it has been difficult to introduce nucleic acid sequences into adipocytes,” the patent application’s abstract states. “Methods are described [in the application] for introducing nucleic acids such as siRNAs into adipocytes, including the introduction of sequences targeting Akt1, Akt2 and Myo1c. Methods for identifying genes involved in glucose transport and for identifying insulin response modulators are described [as are] … therapeutic methods,” the abstract notes.