Oligo Safety Group Recommends Continued Focus on Hybridization-Dependent Off-Target Effects | GenomeWeb

By Doug Macron

BETHESDA, Md. — As improvements in chemical modifications and delivery technologies boost the potency of oligonucleotide-based therapeutics, developers of such drugs must remain vigilant about the potential for hybridization-dependent off-target effects, according to a group of researchers from the industrial, academic, and regulatory fields.

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